Oxalate Reducing Enzyme

Enjoy the foods you love with an oxalate-reducing enzyme*

Nephure is the first-to-market enzyme to reduce oxalates*

Easy To Use

Easy To Use

You can enjoy some of your favorite meals wherever your day may take you. Just grab some of Nephure’s easy-to-use stick packs and stir one into the beverage enjoyed with your meals.

Less Hassle

Less Hassle

Have you ever prepared one plate different from the others at the table or had everyone have the low-oxalate plate too? Nephure offers more flexibility, a simpler menu and less hassle at family mealtime.

Essentially Tasteless

Essentially Tasteless

Now you can mix one packet of Nephure with your beverage during your two main meals daily and savor the flavors you’ve missed on your low-oxalate diet.

How Nephure Works - The Science

Nephure contains an enzyme called oxalate decarboxylase. This enzyme splits oxalate into smaller compounds naturally present in your body. The reaction starts with the enzyme binding oxalate ultimately pulling it apart into smaller pieces resulting in reduced oxalate levels.

Meet The Team Behind Nephure ›

Try Nephure With These Foods!
Throughout our research studies, we have tested foods for oxalate reduction with the Nephure enzyme that you would normally have at home or grab on-the-go.


  • Black Tea
  • Green Tea
  • Peach Tea
  • Tea with Lemon
  • Tea with Lemonade
  • Lemonade
  • Orange Juice
  • Cranberry Juice
  • Grape Juice
  • Grapefruit Juice
  • Blueberry Juice
  • Pomegranate Juice
  • Pineapple Juice
  • Black Cherry Juice
  • Lemon Juice
  • Beet Juice
  • Tomato Juice
  • Carrot Juice
  • Green Juice
  • Fruit Punch Sports Drink
  • Soy Milk
  • Chocolate Milk
  • Non-dairy Milk
  • Almond Milk
  • Cashew Milk
  • Coconut Milk
  • French Vanilla Creamer
  • Hazelnut Creamer
  • Black Coffee
  • Iced Coffee
  • Caramel-Flavored Iced Coffee
  • Organic Cold-Brew Black Coffee
  • Fruit Drinks and Smoothies
  • Cola Soda
  • Beer


  • Soups
  •     Creamy Tomato
  •     Condensed Tomato
  •     Lentil
  •     Clam Chowder
  • Canned Fruits
  •     Oranges
  •     Pear Halves
  •     Peach Slices
  •     Pineapple Slices
  • Canned Vegetables
  •     Olives
  •     Carrots
  •     Tomatoes
  •     Green Beans
  •     Spinach
  •     Veggie Blends
  •     Corn
  • Canned Black Beans
  • Canned Baked Beans
  • Cocoa Beans
  • Wheat
  • Soy Sauce
  • Red Wine Vinegar
  • Balsamic Vinegar
  • Vanilla Extract
  • Almond Extract


  • Peanut Butter and Jelly Sandwich
  • Chicken Entree with Green Beans and Carrots
  • Spinach Salad with Dressing
  • Pasta with Marinara Sauce
  • Fresh Fruit Smoothie

If you have questions on foods you often eat, and can't find it in the list below, send us a note!


*Based on testing in simulated stomach environment.

Frequently Asked Questions

  • What is oxalate and where does it come from?

    Oxalate is the chemical outcome of metabolism in plants. While oxalate serves an important role in the growth and regulatory functions of plants, it serves no known benefit for your body. Oxalate that you consume becomes a waste product and is disposed of through the kidneys and urinary tract. Oxalate is also considered an “anti-nutrient” because it binds with nutrients we need, like calcium, magnesium and iron, making them less available for your body.

  • How does oxalate affect us?

    Oxalate is considered an “anti-nutrient” because it binds with nutrients we need, like calcium, magnesium and iron, making them less available for your body. The oxalate you consume through your diet becomes a waste product and is disposed of through the kidneys and urinary tract.

  • What is the recommended oxalate intake per day?

    If recommended to be on a low-oxalate diet, the ideal oxalate intake is about 50 mg per day. For reference, the average person consumes about 250 mg of oxalate per day.

  • How do you define a food/beverage low in oxalate?

    We define low-oxalate foods to have between 0 - 2 mg of oxalate per 100 g serving. Medium or moderate levels are defined as 2-10 mg per 100 g serving; any servings above 10 mg of oxalate are considered high.

  • What is a low-oxalate diet?

    The traditional low-oxalate diet requires reducing or eliminating oxalate-packed foods, which include anything from spinach and nuts to potatoes and chocolate. A low-oxalate diet is recommended to a growing number of people as part of an overall program to help maintain kidney and urinary tract health. Please check with your healthcare professional for more information on things to include in your kidney health program.

  • What is Nephure?

    The Nephure Oxalate-Reducing Enzyme is an innovative product that reduces the levels of oxalate in a variety of foods and beverages* to help with your kidney-friendly, low-oxalate diet. When purchased, you will receive a Nephure box with 30 stick packs for easier, on-the-go use with your low-oxalate diet.

  • What is an enzyme?

    Enzymes are specialized proteins that accelerate chemical reactions. Enzymes are present in nearly all foods and are used in many applications including the production of breads and baked goods and many other consumer products.

  • Where can I find allergy and nutrition information?

    Ingredients: Maltodextrin (non-GMO corn starch), oxalate decarboxylase enzyme

    This product was manufactured in a facility that also processes peanuts, tree nuts, corn, milk ingredients, eggs, soy, wheat, crustaceans and fish.

  • How do I order Nephure?

    You can find Nephure in our online shop here.

  • How often should I use Nephure?

    The suggested use is twice daily with your two largest meals - mix with a 6 oz. beverage (below 140 degrees Fahrenheit) that will be consumed with that meal. It is recommended not to exceed 3 packets per day.

  • What is the difference between Potassium Citrate and Nephure?

    The main mechanisms of Potassium Citrate is that it raises the pH of the urine discouraging certain crystal formation. It also binds up calcium so that it cannot bind oxalate. Nephure has a more direct approach in the sense that it breaks down oxalate in food thereby making sure it is not there in the first place! Nephure helps you digest oxalate so that your body can put it to better use.

  • Is Nephure non-GMO?

    The maltodextrin used in Nephure is from non-GMO corn starch.

  • Is Nephure gluten free?

    Yes, Nephure is gluten free.

  • Is Nephure made in the USA?

    Nephure is proudly made in the USA with carefully selected ingredients of international and domestic origin. 

  • What is your return policy?

    We're confident in Nephure and we want you to be confident, too! That's why we back every box of Nephure with a 30-day money back guarantee.

    To learn more visit 30-Day Money Back Guarantee

Why Choose Nephure?

icon-usa Proudly made in the USA with carefully selected ingredients of international and domestic origin
icon-aua Nephure’s purpose is to assist you in limiting the intake of oxalate-dense foods as recommended by the AUA guidelines.**
icon-fda Manufactured in a Food and Drug Administration (FDA) registered facility complying with cGMP
icon-gluten Gluten Free
icon-lab Lab Tested

Product is lab tested to assure accuracy and quality
icon-sodium Sodium Free
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**AUA Guidelines on the Dietary Management of Kidney Stones (Diet Therapies #10)
The Nephure Low-Oxalate Shop: Because food is life Scale down the hard work of  a low-oxalate diet and enjoy some of the foods you love during family mealtime  with less hassle. Visit the Nephure Low-Oxalate Shop, and experience how to  make your kidney health program easier. Shop Now ›

What do Nephure Customers Have to Say?

Finallya product which allows me to return to some of my cherished foods without guilt! Thank you, Nephure!"
I limit my consumption of oxalates but when I slip up (usually after eating out), I reach for Nephure and it helps so much."